Cannabis sativa L. has been utilized for therapy of discomfort and sleep problems given that ancient occasions. This critique examines contemporary research on effects of Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on sleep. It goes on to report new data on the effects on sleep in the context of health-related treatment of neuropathic discomfort and symptoms of a number of sclerosis, employing standardized oromucosal cannabis-primarily based medicines containing mostly THC, CBD, or a 1 : 1 mixture of the two (Sativex). Sleep-laboratory benefits indicate a mild activating impact of CBD, and slight residual sedation with THC-predominant extracts. Knowledge to date with Sativex in several Phase I-III research in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in sufferers with a wide assortment of discomfort circumstances like a number of sclerosis, peripheral neuropathic discomfort, intractable cancer pain, and rheumatoid arthritis, with an acceptable adverse occasion profile. No tolerance to the advantage of Sativex on discomfort or sleep, nor need to have for dosage increases have been noted in security extension research of up to 4 years, wherein 40-50% of subjects attained great or quite great sleep high-quality, a important supply of disability in chronic discomfort syndromes that may possibly contribute to patients’ high-quality of life.
Copyright © 2018 Elsevier B.V. All rights reserved.
PMID: 17712817 DOI: 10.1002/cbdv.200790150
Russo EB1, Guy GW, Robson PJ.